Introduction. In Ethiopia, it is the second cause for clinical presentation among under five-year child population. Objective. The\nmain aim of this study was to assess knowledge, practice, and associated factors of home-based management of diarrhea among\ncaregivers of children attending the under-five clinic. Methods. Institution based quantitative cross-sectional study was carried out\nfromMarch 1, 2016, to April 22, 2016. Results. Two hundred eight (56.2%) of them had good knowledge and one hundred thirtynine\n(37.6%) of them had the good practice of home management of diarrhea, specifically, primary education (AOR: 5.384, 95%\nCI: 2.008, 14.438), secondary and above education (AOR: 11.769, 95% CI: 3.527, 39.275), daily laborer (AOR: 0.208, 95% CI: 0.054,\n0.810), and no information about diarrhea (AOR: 0.139, 95% CI: 0.054, 0.354). Moreover, age range of 25ââ?¬â??35 (AOR: 4.091, 95% CI:\n1.741, 9.616) and 36ââ?¬â??45 (AOR: 3.639, 95% CI: 1.155, 11.460), being single (AOR: 0.111, 95% CI: 0.013, 0.938), being divorced (AOR:\n0.120, 95% CI: 0.024, 0.598), illiteracy (AOR: 0.052, 95% CI: 0.017, 0.518), primary education (AOR: 0.143, CI: 0.046, 0.440), and no\ninformation about diarrhea (AOR: 0.197, 95% CI: 0.057, 0.685) were significantly associated variables with the outcome variables in\nmultivariate regression. Conclusion. Caregivers had slightly adequate knowledge but poor practice.
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